Karthik Ganesh

CEO, EmpiRx Health & Author, The Happiness Model

Karthik Ganesh is the CEO at EmpiRx Health, a category creator and the industry’s only value-based PBM, with a clinically-focused and tech-enabled approach to bending the Rx cost curve. Karthik has built EmpiRx Health into an Inc. 1000 company and certified Great Place To Work, while transforming it into a high-growth and high-innovation engine.


Karthik is a senior healthcare executive with a solid track record of comprehensively growing, transforming, and maximizing value at tech-enabled health service companies while driving dramatic before-and-after results across all facets of the organization - growth and retention, financials, business operations, technology, and culture.


Prior to EmpiRx Health, Karthik was the founding operations leader of CareAllies, a Cigna subsidiary focused on value-based care enablement. As EVP and COO of QualCare, Karthik transformed a large provider-sponsored third-party administrator into a tech-enabled health services powerhouse, that specialized in powering and operating health plans, value-based shared savings models, Accountable Care Organizations (ACOs), and joint payer-provider strategies. Karthik’s background includes leadership roles at Aetna and Express Scripts, and senior management consulting roles at Deloitte and EY. He is recognized as a thought leader on healthcare, leadership, and resilience. Karthik is a published author and has been featured in leading industry journals.